From those you listed, the only person that was willing to cross party lines was John McCain.
Manchin, Sinema basically are Republicans that just run as Democrats, their voting record shows that (especially Sinema outraged her voters, because she changed after being elected, Manchin doesn't hide who he is, so I have less problem with him). Lieberman is just spiteful and was willing torpedo single payer that he himself was pushing, because he lost primaries). Murkowski only says that she is moderate, but she still votes with the party when her vote would actually made any difference.
McCain was a Republican and believed that is the right way, but unlike those rest you listed he put country first. If you would have discussion with him and convince him that specific bill actually benefits Americans he had no problem to vote against his party (last example was where he actually stopped repeal of ACA).