Interesting article but not really what we’re looking for:
<span style="color:#323232;">This option is especially useful for computers with multiple users and for when you don't want executable files running from a user profile.
</span><span style="color:#323232;">Other than where the sync app is installed, the behavior is the same.
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It’s not the installation but the configuration that is causing trouble. FSLogix would require on-prem hardware.