I believe Heisenberg says there’s vagueness in the amount of things we can know at once. But I agree there’s nothing we shouldn’t be able to know, only things we know that we can’t know simultaneously, which imo is “vagueness”. However the understand principle is something I hope falls some day with better measurement devices than we had a hundred years ago.
Also everyone should listen to Sabine, she’s among the least biased science educators imo. People need to be really careful what they learn from YouTube creators, in fact that was a subject of a recent Sabine video!