Oh yeah for sure, I don’t mean at all to say that all questions have been answered, and even the answers that we do have get more and more vague as you move down the science purity ladder. If all questions were solved, we would be out of a job for one! But I choose to interpret OP’s question as “is there anything unknowable?”. That’s the question relevant to our world right now, and I often disagree with the world view implied by popular science - that the world is full of wonder but also mystery. The mystery is not fundamental, but rather an expression of our individual and collective ignorance. There are even plenty of questions, like the delayed-choice quantum eraser, that have already been solved, and yet they keep popping up as examples of the unknowable, one even sniped me in this very thread (hi there!). Then people say “you do not even know whether eating eggs is good for you” and therefore by implication we shouldn’t listen to scientists at all. In that sense, the proliferation of the idea of mystery has become dangerous. The answer to unanswered questions is not gnosticism, it is as you said “further research” 😄!