Permanent injury and disability is unlikely. Chronic pain is likely a nonissue. Most of the unpredictable diseases can be sciencemagick'd away. Even old age, you'll still be mobile, active, and happy. Long, thriving lives are the minimum expectation.
In a world where medical technology is so good that only "natural" death will get you in the end, and one where there's no resource constraint forcing you to a stressful and awful life with no opportunity to thrive, everyone kind of has a lot more to lose. I might be more willing to do something "risky", but not if that risk contains "risk of immediate death" because there's no fixing that.
Though whether this is the way human psychology works... who knows.