At school, I thought our understanding of chemistry was really good. Years later, I realized that complicated solutions aren’t covered by any of the equations we have. You’re can do fancy calculations, but you’re always stuck with simple solutions and standard conditions. In real life, you have to deal with super messy non-standard stuff all the time.
Top scientists end up developing semi-empirical models, or even particle simulations, and that’s the best we can do right now. Nobody fully trusts those predictions, so we’re still going to need lab experiments before making any big decisions.
The good news is that there’s still so much to discover.