I do use iSCSI between my Proxmox server any my TrueNAS server. What do you mean by “noise,” exactly? My understanding is that because iSCSI isn’t broadcasting, my switch is only going to transfer packets between the two servers, which would prevent any “noise” from making it out to other devices on other ports.
iSCSI is block level storage where NFS/SMB are file level… When you browse a folder with SMB/NFS it is going to ask the remote service for the meta file list then cache the whole thing till it thinks it needs it refreshed… iSCSI is going to go read a set of blocks to read the metadata off the remote file system. iSCSI can be considerably more chatty between the two hosts as it is lower level.