Dealing with monopolies, stopping our unilateral support for Israel, fixing the housing crisis, and proper taxation for the wealthiest so that a lot of the public institutions that have been defunded for the past couple decades can be improved. Those are the biggest ones, fix those and most of the other ones start to self correct. Don't, and the US falls apart.
xkcd #2948: Electric vs Gas ( xkcd.com )
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What issues motivate voters who support neither Biden nor Trump? ( www.npr.org )